https://mail.pjbmb.com/index.php/pjbmb <div class="fw-row"> <div class="fw-col-xs-12"> <div class="seline-default-heading"> <p>The Pakistan Journal of Biochemistry and Molecular Biology (PJBMB) (ISSN P 1681-4525; ISSN E 2788-4147) is an open-access journal that publishes papers that contribute to knowledge in the field of Biochemistry, Molecular Biology, and related areas.</p> <p>PJBMB is currently published under the auspices of Mohammad Ali Jinnah University in Karachi, Pakistan.</p> <p>An article for publication must describe substantial original research undertaken according to the scope of this journal. A manuscript submitted for publication implies that the work described has not been published before (except as an abstract or a published lecture, review, or thesis). At the time of its submission to PJBMB it should neither be under consideration for publication elsewhere nor will it be reproduced after its publication in any other journal. Any co-authors must have agreed with the contents of the publication including the institution where the work was carried out. All authors should have agreed to the automatic transfer of copyright to the Editor-in-Chief of PJBMB.</p> <p>Since 1968, the Pakistan Journal of Biochemistry and Molecular Biology (PJBMB) has been consistently published as the official publication of the Pakistan Society of Biochemistry and Molecular Biology. As a result, it stands as one of the nation’s most longstanding scholarly periodicals.</p> <p>Since 2010, volumes of PJBMB is being published online (ISSN E 2788-4147). Recently, PJBMB has established online journal publishing with the help of "Open Journal Systems" (OJS). The OJS is an open-source software application for managing and publishing scholarly journals.</p> <p>PJBMB volumes published since 2018 to date are available online at pjbmb.com. Whereas, volumes published during 2010-2017 can be accessed at www.pjbmb.org.pk.</p> </div> </div> </div> Pakistan Society of Biochemistry and Molecular Biology en-US PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 1681-4525 https://mail.pjbmb.com/index.php/pjbmb/article/view/198 <p>The traditional perspective views cancer as epigenetic disease. However, this review highlights the dynamic interplay between epigenetics and metabolism, where oncometabolites reshape the molecular architecture of the tumor microenvironment (TME). We explore how mutations in tricarboxylic acid (TCA) cycle enzymes (IDH, SDH, FH) or stress-induced metabolic reprogramming lead to the accumulation of metabolites such as D-2-hydroxyglutarate (D2HG), succinate, and fumarate. These oncometabolites act as competitive inhibitors of α-ketoglutarate–dependent dioxygenases, driving DNA hypermethylation, histone modifications, pseudohypoxia, and epitranscriptomic changes such as m6A methylation. Importantly, this crosstalk extends beyond cancer cells, reshaping immune function, promoting T-cell exhaustion via histone lactylation, and influencing ferroptosis. We also discuss emerging therapeutic strategies, including mutant IDH inhibitors, nanomedicine approaches, and AI-driven multi-omics, while acknowledging challenges posed by tumor heterogeneity and metabolic plasticity. Understanding the epigenetic–metabolic axis opens promising avenues for precision and translational oncology.</p> Muzamil Hussain Copyright (c) 2026 PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 2026-08-31 2026-08-31 59 1 1 21